Preface/Table of Contents


Table of Contents

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Part 1 General Considerations in Clinical Medicine
General Considerations in Clinical Medicine
1 The Practice of Medicine
    The Editors

2 Global Issues in Medicine
    Paul Farmer, Joseph Rhatigan

3 Decision-Making in Clinical Medicine
    Daniel B. Mark, John B. Wong

4 Screening and Prevention of Disease
    Katrina Armstrong, Gary J. Martin

5 Principles of Clinical Pharmacology
    Dan M. Roden

6e Women’s Health
    Andrea Dunaif

7e Men’s Health
    Shalender Bhasin, Shehzad Basaria

8 Medical Disorders During Pregnancy
    Robert L. Barbieri, John T. Repke

9 Medical Evaluation of the Surgical Patient
    Wei C. Lau, Kim A. Eagle

10 Palliative and End-of-Life Care
    Ezekiel J. Emanuel

11 Clinical Problems of Aging
    Luigi Ferrucci, Stephanie Studenski

12e The Safety and Quality of Health Care
    David W. Bates

13e Primary Care in Low- and Middle-income Countries
    Tim Evans, Kumanan Rasanathan

14e Complementary, Alternative, and Integrative Health Practices
    Josephine P. Briggs

15e The Economics of Medical Care
    Joseph P. Newhouse

16e Racial and Ethnic disparities in Health Care
    Joseph R. Betancourt, Alexander R. Green

17e Ethical issues in Clinical Medicine
    Bernard Lo, Christine Grady

Part 2 Cardinal Manifestations and Presentation of Diseases
Section 1 Pain
18 Pain: Pathophysiology and Management
    James P. Rathmell, Howard L. Fields

19 Chestdiscomfort
    David A. Morrow

20 Abdominal Pain
    Danny O. Jacobs, William Silen

21 Headache
    Peter J. Goadsby, Neil H. Raskin

22 Back and Neck Pain
    John W. Engstrom, Richard A. Deyo

Section 2 Alterations in Body Temperature
23 Fever
    Charles A. Dinarello, Reuven Porat

24 Fever and Rash
    Elaine T. Kaye, Kenneth M. Kaye

25e Atlas of Rashes Associated with Fever
    Kenneth M. Kaye, Elaine T. Kaye

26 Fever of Unknown Origin
    Chantal P. Bleeker-Rovers, Jos W. M. van der Meer

Section 3 Nervous System Dysfunction
27 Syncope
    Roy Freeman

28 Dizziness and Vertigo
    Mark F. Walker, Robert B. Daroff

29 Fatigue
    Jeffrey M. Gelfand, Vanja C. Douglas

30 Neurologic Causes of Weakness and Paralysis
    Michael J. Aminoff

31 Numbness, Tingling, and Sensory Loss
    Michael J. Aminoff

32 Gait and Balance Disorders
    Lewis Sudarsky

33e video Library of Gait Disorders
    Gail Kang, Nicholas B. Galifianakis, Michael D. Geschwind

34 Confusion and Delirium
    S. Andrew Josephson, Bruce L. Miller

35 Dementia
    William W. Seeley, Bruce L. Miller

36 Aphasia, Memory Loss, and other focal Cerebraldisorders
    M.-Marsel Mesulam

37e Primary Progressive Aphasia, Memory Loss, and Other Focal Cerebral Disorders
    Maria Luisa Gorno-Tempini, Jennifer Ogar, Joel Kramer, Bruce L. Miller, Gil Rabinovici, Maria Carmela Tartaglia

38 Sleepdisorders
    Charles A. Czeisler, Thomas E. Scammell, Clifford B. Saper

Section 4 Disorders of Eyes, Ears, Nose, and Throat
39 Disorders of the Eye
    Jonathan C. Horton

40e Use of the Hand-Held Ophthalmoscope
    Homayoun Tabandeh, Morton F. Goldberg

41e Video Library of Neuro-ophthalmology
    Shirley H. Wray

42 Disorders of Smell and Taste
    Richard L. Doty, Steven M. Bromley

43 Disorders of Hearing
    Anil K. Lalwani

44 Sore Throat, Earache, and Upper Respiratory Symptoms
    Michael A. Rubin, Larry C. Ford, Ralph Gonzales

45 Oral Manifestations of Disease
    Samuel C. Durso

46e Atlas of Oral Manifestations of Disease
    Samuel C. Durso, Janet A. Yellowitz

Section 5 Alterations in Circulatory and Respiratory Functions
47e Dyspnea
    Richard M. Schwartzstein

48 Cough and Hemoptysis
    Patricia A. Kritek, Christopher H. Fanta

49 Hypoxia and Cyanosis
    Joseph Loscalzo

50 Edema
    Eugene Braunwald, Joseph Loscalzo

51e Approach to the Patient with a Heart Murmur
    Patrick T. O’Gara, Joseph Loscalzo

52 Palpitations
    Joseph Loscalzo

Section 6 Alterations in Gastrointestinal Function
53 Dysphagia
    Ikuo Hirano, Peter J. Kahrilas

54 Nausea, Vomiting, and Indigestion
    William L. Hasler

55 Diarrhea and Constipation
    Michael Camilleri, Joseph A. Murray

56 involuntary Weight Loss
    Russell G. Robertson, J. Larry Jameson

57 Gastrointestinal Bleeding
    Loren Laine

58 Jaundice
    Savio John, Daniel S. Pratt

59 Abdominal Swelling and Ascites
    Kathleen E. Corey, Lawrence S. Friedman

Section 7 Alterations in Renal and Urinary Tract Function
60e Dysuria, Bladder Pain, and the interstitial Cystitis/Bladder Pain Syndrome
    John W. Warren

61 Azotemia and urinary Abnormalities
    Julie Lin, Bradley M. Denker

62e Atlas of Urinary Sediments and Renal Biopsies
    Agnes B. Fogo, Eric G. Neilson

63 Fluid and Electrolyte Disturbances
    David B. Mount

64e Fluid and Electrolyte imbalances and Acid-Base Disturbances: Case Examples
    David B. Mount, Thomas D. DuBose, Jr.

65 Hypercalcemia and Hypocalcemia
    Sundeep Khosla

66 Acidosis and Alkalosis
    Thomas D. DuBose, Jr.

Section 8 Alterations in Sexual Function and Reproduction
67 Sexual Dysfunction
    Kevin T. McVary

68 Hirsutism
    David A. Ehrmann

69 Menstrual Disorders and Pelvic Pain
    Janet E. Hall

Section 9 Alterations in the Skin
70 Approach to the Patient with a Skin Disorder
    Thomas J. Lawley, Kim B. Yancey

71 Eczema, Psoriasis, Cutaneous infections, Acne, and other Common Skin Disorders
    Leslie P. Lawley, Calvin O. McCall, Thomas J. Lawley

72 Skin Manifestations of Internal Disease
    Jean L. Bolognia, Irwin M. Braverman

73 Immunologically Mediated Skin Diseases
    Kim B. Yancey, Thomas J. Lawley

74 Cutaneous Drug Reactions
    Kanade Shinkai, Robert S. Stern, Bruce U. Wintroub

75 Photosensitivity and Other Reactions to Light
    Alexander G. Marneros, David R. Bickers

76e Atlas of Skin Manifestations of Internaldisease
    Thomas J. Lawley, Calvin O. McCall, Robert A. Swerlick

Section 10 Hematologic Alterations
77 Anemia and Polycythemia
    John W. Adamson, Dan L. Longo

78 Bleeding and Thrombosis
    Barbara A. Konkle

79 Enlargement of Lymph Nodes and Spleen
    Patrick H. Henry, Dan L. Longo

80 Disorders of Granulocytes and Monocytes
    Steven M. Holland, John I. Gallin

81e Atlas of Hematology and Analysis of Peripheral Blood Smears
    Dan L. Longo

Part 3 Genes, the Environment, and Disease
Genes, the Environment, and Disease
82 Principles of Human Genetics
    J. Larry Jameson, Peter Kopp

83e Chromosomedisorders
    Nancy B. Spinner, Laura K. Conlin

84 The Practice of Genetics in Clinical Medicine
    Susan M. Domchek, J. Larry Jameson, Susan Miesfeldt

85e Mitochondrial DNA and Heritable Traits and Diseases
    Karl Skorecki, Doron Behar

86e The Human Microbiome
    Jeffrey I. Gordon, Rob Knight

87e Network Medicine: Systems Biology in Health and Disease
    Joseph Loscalzo

Part 4 Regenerative Medicine
Regenerative Medicine
88 Stem Cell Biology
    Minoru S. H. Ko

89e Hematopoietic Stem Cells
    David T. Scadden, Dan L. Longo

90e Applications of Stem Cell Biology in Clinical Medicine
    John A. Kessler

91e Gene Therapy in Clinical Medicine
    Katherine A. High

92e Tissue Engineering
    Anthony Atala

Part 5 Aging
93e World Demography of Aging
    Richard M. Suzman, John G. Haaga

94e The Biology of Aging
    Rafael de Cabo, David G. Le Couteur

Part 6 Nutrition and Weight Loss
Nutrition and Weight Loss
95e Nutrient Requirements and Dietary Assessment
    Johanna Dwyer

96e vitamin and trace Mineral Deficiency and Excess
    Robert M. Russell, Paolo M. Suter

97 Malnutrition and Nutritional Assessment
    Douglas C. Heimburger

98e Enteral and Parenteral Nutrition Therapy
    Bruce R. Bistrian, L. John Hoffer, David F. Driscoll

Part 7 Oncology and Hematology
Section 1 Neoplastic Disorders
99 Approach to the Patient with Cancer
    Dan L. Longo

100 Prevention and Early detection of Cancer
    Jennifer M. Croswell, Otis W. Brawley, Barnett S. Kramer

101e Cancer Genetics
    Pat J. Morin, Jeffrey M. Trent, Francis S. Collins, Bert Vogelstein

102e Cancer Cell Biology
    Jeffrey W. Clark, Dan L. Longo

103e Principles of Cancer treatment
    Edward A. Sausville, Dan L. Longo

104 infections in Patients with Cancer
    Robert W. Finberg

105 Cancer of the skin
    Walter J. Urba, Brendan D. Curti

106 Head and neck Cancer
    Everett E. Vokes

107 Neoplasms of the Lung
    Leora Horn, Christine M. Lovly, David H. Johnson

108 Breast Cancer
    Marc E. Lippman

109 Upper Gastrointestinal tract Cancers
    Robert J. Mayer

110 Lower Gastrointestinal Cancers
    Robert J. Mayer

111 Tumors of the Liver and Biliary Tree
    Brian I. Carr

112 Pancreatic Cancer
    Elizabeth Smyth, David Cunningham

113 Endocrine tumors of the Gastrointestinal Tract and Pancreas
    Robert T. Jensen

114 Bladder and Renal Cell Carcinomas
    Howard I. Scher, Jonathan E. Rosenberg, Robert J. Motzer

115 Benign and Malignant Diseases of the Prostate
    Howard I. Scher, James A. Eastham

116 Testicular Cancer
    Robert J. Motzer, Darren R. Feldman, George J. Bosl

117 Gynecologic Malignancies
    Michael V. Seiden

118 Primary and Metastatic Tumors of the Nervous System
    Lisa M. DeAngelis, Patrick Y. Wen

119e Soft Tissue and Bone Sarcomas andvBone Metastases
    Shreyaskumar R. Patel, Robert S. Benjamin

120e Carcinoma of Unknown Primary
    Gauri R. Varadhachary, James L. Abbruzzese

121 Paraneoplastic Syndromes: Endocrinologic/Hematologic
    J. Larry Jameson, Dan L. Longo

122 Paraneoplastic neurologic syndromes and Autoimmune Encephalitis
    Josep Dalmau, Myrna R. Rosenfeld

123e Thymoma
    Dan L. Longo

124e Neoplasia During Pregnancy
    Michael F. Greene, Dan L. Longo

125 Late Consequences of Cancer and its Treatment
    Carl E. Freter, Dan L. Longo

Section 2 Hematopoietic Disorders
126 Iron Deficiency and Other Hypoproliferative Anemias
    John W. Adamson

127 Disorders of Hemoglobin
    Edward J. Benz, Jr.

128 Megaloblastic Anemias
    A. Victor Hoffbrand

129 Hemolytic Anemias and Anemia Due to Acute Blood Loss
    Lucio Luzzatto

130 Bone Marrow Failure Syndromes Including Aplastic Anemia and Myelodysplasia
    Neal S. Young

131 Polycythemia Vera and Other Myeloproliferative Neoplasms
    Jerry L. Spivak

132 Acute Myeloid Leukemia
    Guido Marcucci, Clara D. Bloomfield

133 Chronic Myeloid Leukemia
    Hagop Kantarjian, Jorge Cortes

134 Malignancies of Lymphoid Cells
    Dan L. Longo

135e Less Common Hematologic Malignancies
    Ayalew Tefferi, Dan L. Longo

136 Plasma Cell Disorders
    Nikhil C. Munshi, Dan L. Longo, Kenneth C. Anderson

137 Amyloidosis
    David C. Seldin, John L. Berk

138e Transfusion Biology and Therapy
    Jeffery S. Dzieczkowski, Kenneth C. Anderson

139e Hematopoietic Cell Transplantation
    Frederick R. Appelbaum

Section 3 Disorders of Hemostasis
140 Disorders of Platelets and Vessel Wall
    Barbara A. Konkle

141 Coagulation Disorders
    Valder R. Arruda, Katherine A. High

142 Arterial and Venous Thrombosis
    Jane E. Freedman, Joseph Loscalzo

143 Antiplatelet, Anticoagulant, and Fibrinolytic Drugs
    Jeffrey I. Weitz

Part 8 Infectious Diseases
Section 1 Basic Considerations in Infectious Diseases
144 Approach to the Patient with an infectiousdisease
    Neeraj K. Surana, Dennis L. Kasper

145e Molecular Mechanisms of Microbial Pathogenesis
    Gerald B. Pier

146 Genomics and Infectious Disease
    Roby P. Bhattacharyya, Yonatan H. Grad, Deborah T. Hung

147 Approach to the Acutely Ill Infected Febrile Patient
    Tamar F. Barlam, Dennis L. Kasper

148 Immunization Principles and Vaccine Use
    Anne Schuchat, Lisa A. Jackson

149 Health Recommendations for International Travel
    Jay S. Keystone, Phyllis E. Kozarsky

150e Laboratory Diagnosis of Infectious Diseases
    Alexander J. McAdam, Andrew B. Onderdonk

151e Climate Change and Infectious Disease
    Aaron S. Bernstein

152e Infections in Veterans Returning from Foreign Wars
    Andrew W. Artenstein

Section 2 Clinical Syndromes: Community-Acquired Infections
153 Pneumonia
    Lionel A. Mandell, Richard G. Wunderink

154 Lung Abscess
    Rebecca M. Baron, Miriam Baron Barshak

155 Infective Endocarditis
    Adolf W. Karchmer

156 Infections of the skin, Muscles, and Soft Tissues
    Dennis L. Stevens

157 Infectious Arthritis
    Lawrence C. Madoff

158 osteomyelitis
    Werner Zimmerli

159 Intraabdominal Infections and Abscesses
    Miriam Baron Barshak, Dennis L. Kasper

160 Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning
    Regina C. LaRocque, Edward T. Ryan, Stephen B. Calderwood

161 Clostridium Difficile Infection, Including Pseudomembranous Colitis
    Dale N. Gerding, Stuart Johnson

162 Urinary Tract Infections, Pyelonephritis, and Prostatitis
    Kalpana Gupta, Barbara W. Trautner

163 Sexually transmitted infections: Overview and Clinical Approach
    Jeanne M. Marrazzo, King K. Holmes

164 Meningitis, Encephalitis, Brain Abscess, and Empyema
    Karen L. Roos, Kenneth L. Tyler

165 Chronic and recurrent Meningitis
    Walter J. Koroshetz, Avindra Nath

166e Infectious Complications of Burns
    Lawrence C. Madoff, Florencia Pereyra

167e Infectious Complications of Bites
    Lawrence C. Madoff, Florencia Pereyra

Section 3 Clinical Syndromes: Health Care–associated Infections
168 Infections Acquired in Health Care Facilities
    Robert A. Weinstein

169 Infections in Transplant Recipients
    Robert W. Finberg, Joyce Fingeroth

Section 4 Approach to Therapy for Bacterial Diseases
170 Treatment and Prophylaxis of Bacterial Infections
    David C. Hooper, Erica S. Shenoy, Christy A. Varughese

Section 5 Diseases Caused By Gram-Positive Bacteria
171 Pneumococcal Infections
    David Goldblatt, Katherine L. O’Brien

172 Staphylococcal Infections
    Franklin D. Lowy

173 Streptococcal Infections
    Michael R. Wessels

174 Enterococcal Infections
    Cesar A. Arias, Barbara E. Murray

175 Diphtheria and other Corynebacterial Infections
    William R. Bishai, John R. Murphy

176 Listeria Monocytogenes Infections
    Elizabeth L. Hohmann, Daniel A. Portnoy

177 Tetanus
    C. Louise Thwaites, Lam Minh Yen

178 Botulism
    Susan Maslanka, Agam K. Rao

179 Gas Gangrene and Other Clostridial Infections
    Amy E. Bryant, Dennis L. Stevens

Section 6 Diseases Caused By Gram-negative Bacteria
180 Meningococcalinfections
    Andrew J. Pollard

181 Gonococcal Infections.
    Sanjay Ram, Peter A. Rice

182 HaemophilusandMoraxella Infections
    Timothy F. Murphy

183e Infections due to the HACEK Group and Miscellaneous Gram-negative Bacteria
    Tamar F. Barlam, Dennis L. Kasper

184 Legionellainfections
    Victor L. Yu, M. Luisa Pedro-Botet, Yusen E. Lin

185 Pertussis and other Bordetella iInfections
    Karina A. Top, Scott A. Halperin

186 Diseases Caused by Gram-negative Enteric Bacilli
    Thomas A. Russo, James R. Johnson

187 Acinetobacter Infections
    David L. Paterson, Anton Y. Peleg

188 Helicobacter Pylori Infections
    John C. Atherton, Martin J. Blaser

189 Infections Due to Pseudomonas species and Related Organisms
    Reuben Ramphal

190 Salmonellosis
    David A. Pegues, Samuel I. Miller

191 Shigellosis
    Philippe J. Sansonetti, Jean Bergounioux

192 infections Due to Campylobacter and Related Organisms
    Martin J. Blaser

193 Cholera and Other Vibrioses
    Matthew K. Waldor, Edward T. Ryan

194e Brucellosis
    Nicholas J. Beeching, Michael J. Corbel

195 Tularemia
    Richard F. Jacobs, Gordon E. Schutze

196 Plague and other Yersinia Infections
    Michael B. Prentice

197 Bartonella Infections, Including Cat-scratch Disease
    Michael Giladi, Moshe Ephros

198e Donovanosis
    Nigel O’Farrell

Section 7 Miscellaneous Bacterial Infections
199 Nocardiosis
    Gregory A. Filice

200 Actinomycosis and Whipple’s Disease
    Thomas A. Russo

201 Infections Due to Mixed Anaerobic Organisms
    Ronit Cohen-Poradosu, Dennis L. Kasper

Section 8 Mycobacterial Diseases
202 Tuberculosis
    Mario C. Raviglione

203 Leprosy
    Robert H. Gelber

204 Nontuberculous Mycobacterial Infections
    Steven M. Holland

205e Antimycobacterial Agents
    Max R. O’Donnell, Divya Reddy, Jussi J. Saukkonen

Section 9 Spirochetal Diseases
206 Syphilis
    Sheila A. Lukehart

207e Endemic Treponematoses
    Sheila A. Lukehart

208 Leptospirosis
    Rudy A. Hartskeerl, Jiři F. P. Wagenaar

209 Relapsing Fever
    Alan G. Barbour

210 Lyme Borreliosis
    Allen C. Steere

Section 10 Diseases Caused By Rickettsiae, Mycoplasmas, and Chlamydiae
211 Rickettsial Diseases
    David H. Walker, J. Stephen Dumler, Thomas Marrie

212 infections Due to Mycoplasmas
    R. Doug Hardy

213 Chlamydial Infections
    Charlotte A. Gaydos, Thomas C. Quinn

Section 11 Viral Diseases: General Considerations
214e Medicalvirology
    Fred Wang, Elliott Kieff

215e Antiviral Chemotherapy, Excluding Antiretroviral Drugs
    Lindsey R. Baden, Raphael Dolin

Section 12 Infections Due to DNA Viruses
216 Herpes Simplex Virus Infections
    Lawrence Corey

217 Varicella-Zoster Virus Infections
    Richard J. Whitley

218 Epstein-Barr Virus Infections, including Infectious Mononucleosis
    Jeffrey I. Cohen

219 Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8
    Camille Nelson Kotton, Martin S. Hirsch

220e Molluscum Contagiosum, Monkeypox, and other Poxvirus Infections
    Fred Wang

221 Parvovirus Infections
    Kevin E. Brown

222 Human Papillomavirus Infections
    Aaron C. Ermel, Darron R. Brown

Section 13 Infections Due to DNA and RNA Respiratory Viruses
223 Common Viral Respiratory Infections
    Raphael Dolin

224 Influenza
    Yehuda Z. Cohen, Raphael Dolin

Section 14 Infections Due to Human Immunodeficiency Virus and other Human Retroviruses
225e The Human Retroviruses
    Dan L. Longo, Anthony S. Fauci

226 Human Immunodeficiency Virus Disease: Aids and Related Disorders
    Anthony S. Fauci, H. Clifford Lane

Section 15 Infections Due to RNA Viruses
227 viral Gastroenteritis
    Umesh D. Parashar, Roger I. Glass

228 Enterovirus, Parechovirus, and Reovirus Infections
    Jeffrey I. Cohen

229 Measles (rubeola)
    Kaitlin Rainwater-Lovett, William J. Moss

230e Rubella (German Measles)
    Laura A. Zimmerman, Susan E. Reef

231e Mumps
    Steven A. Rubin, Kathryn M. Carbone

232 Rabies and other Rhabdovirus Infections
    Alan C. Jackson

233 Arthropod-Borne and Rodent-Borne Virus Infections
    Jens H. Kuhn, Clarence J. Peters

234 Ebolavirus and Marburgvirus Infections
    Jens H. Kuhn

Section 16 Fungal Infections
235 Diagnosis and Treatment of Fungal Infections
    John E. Edwards, Jr.

236 Histoplasmosis
    Chadi A. Hage, L. Joseph Wheat

237 Coccidioidomycosis
    Neil M. Ampel

238 Blastomycosis
    Donna C. Sullivan, Rathel L. Nolan, III

239 Cryptococcosis
    Arturo Casadevall

240 Candidiasis
    John E. Edwards, Jr.

241 Aspergillosis
    David W. Denning

242 Mucormycosis
    Brad Spellberg, Ashraf S. Ibrahim

243 superficial Mycoses and Less Common Systemic Mycoses
    Carol A. Kauffman

244 Pneumocystis Infections
    Henry Masur, Alison Morris

Section 17 Protozoal and Helminthic Infections: General Considerations
245e Laboratory Diagnosis of Parasitic Infections
    Sharon L. Reed, Charles E. Davis

246e Agents Used to Treat Parasitic Infections
    Thomas A. Moore

Section 18 Protozoal Infections
247 Amebiasis and Infection with Free-Living Amebas
    Rosa M. Andrade, Sharon L. Reed

248 Malaria
    Nicholas J. White, Joel G. Breman

249 Babesiosis
    Edouard G. Vannier, Peter J. Krause

250e Atlas of Blood smears of Malaria and Babesiosis
    Nicholas J. White, Joel G. Breman

251 Leishmaniasis
    Shyam Sundar

252 Chagas disease and African Trypanosomiasis
    Louis V. Kirchhoff, Anis Rassi Jr.

253 Toxoplasma Infections
    Kami Kim, Lloyd H. Kasper

254 Protozoal Intestinal Infections and Trichomoniasis
    Peter F. Weller

Section 19 Helminthic Infections
255e Introduction to Helminthic Infections
    Peter F. Weller

256 Trichinellosis and Other Tissue Nematode Infections
    Peter F. Weller

257 Intestinal Nematode Infections
    Peter F. Weller, Thomas B. Nutman

258 Filarial and Related Infections
    Thomas B. Nutman, Peter F. Weller

259 Schistosomiasis and other Trematode Infections
    Charles H. King, Adel A. F. Mahmoud

260 Cestode Infections
    A. Clinton White, Jr., Peter F. Weller

Part 9 Terrorism and Clinical Medicine
Terrorism and Clinical Medicine
261e Microbial Bioterrorism
    H. Clifford Lane, Anthony S. Fauci

262e Chemical Terrorism
    Charles G. Hurst, Jonathan Newmark, James A. Romano, Jr.

263e Radiation Terrorism
    Christine E. Hill-Kayser, Eli Glatstein, Zelig A. Tochner

Part 10 Disorders of the Cardiovascular System
Section 1 Introduction to CardiovasCular Disorders
264 Approach to the Patient with Possible Cardiovascular Disease
    Joseph Loscalzo

265e Basic Biology of the Cardiovascular System
    Joseph Loscalzo, Peter Libby, Jonathan A. Epstein

266e Epidemiology of Cardiovascular Disease
    Thomas A. Gaziano, J. Michael Gaziano

Section 2 Diagnosis of Cardiovascular Disorders
267 Physical Examination of the Cardiovascular System
    Patrick T. O’Gara, Joseph Loscalzo

268 Electrocardiography
    Ary L. Goldberger

269e Atlas of Electrocardiography
    Ary L. Goldberger

270e noninvasive Cardiac imaging: Echocardiography, Nuclear Cardiology, and Magnetic Resonance/Computed Tomography Imaging
    Marcelo F. Di Carli, Raymond Y. Kwong, Scott D. Solomon

271e Atlas of Noninvasive Imaging
    Marcelo F. Di Carli, Raymond Y. Kwong, Scott D. Solomon

272 Diagnostic Cardiac Catheterization and Coronary Angiography
    Jane A. Leopold, David P. Faxon

Section 3 Disorders of Rhythm
273e Principles of Electrophysiology
    David D. Spragg, Gordon F. Tomaselli

274 The Bradyarrhythmias: Disorders of the Sinoatrial Node
    David D. Spragg, Gordon F. Tomaselli

275 The Bradyarrhythmias: disorders of the Atrioventricular Node
    David D. Spragg, Gordon F. Tomaselli

276 Supraventricular Tachyarrhythmias
    Gregory F. Michaud, William G. Stevenson

277 Ventricular Arrhythmias
    Roy M. John, William G. Stevenson

278e Atlas of Cardiac Arrhythmias
    Ary L. Goldberger

Section 4 Disorders of the Heart
279 Heart Failure: Pathophysiology and Diagnosis
    Douglas L. Mann, Murali Chakinala

280 Heart failure: Management
    Mandeep R. Mehra

281 Cardiac Transplantation and Prolonged Assisted Circulation
    Sharon A. Hunt, Hari R. Mallidi

282 Congenital Heart Disease in the Adult
    Jamil A. Aboulhosn, John S. Child

283 Aorticvalve Disease
    Patrick T. O’Gara, Joseph Loscalzo

284 Mitralvalve Disease
    Patrick T. O’Gara, Joseph Loscalzo

285 Tricuspid and Pulmonic Valve Disease
    Patrick T. O’Gara, Joseph Loscalzo

286 Multiple and Mixed Valvular Heart Disease
    Patrick T. O’Gara, Joseph Loscalzo

287 Cardiomyopathy and Myocarditis
    Neal K. Lakdawala, Lynne Warner Stevenson, Joseph Loscalzo

288 Pericardial Disease
    Eugene Braunwald

289e Tumors and Trauma of the Heart
    Eric H. Awtry, Wilson S. Colucci

290e Cardiac Manifestations of Systemic Disease
    Eric H. Awtry, Wilson S. Colucci

Section 5 Coronary and Peripheral Vascular Disease
291e The Pathogenesis, Prevention, and Treatment of Atherosclerosis
    Peter Libby

292e Atlas of Atherosclerosis
    Peter Libby

293 ischemic Heart Disease
    Elliott M. Antman, Joseph Loscalzo

294 Non-st-segment Elevation Acute Coronary Syndrome (non-st-segment Elevation Myocardial Infarction and Unstable Angina
    Christopher P. Cannon, Eugene Braunwald

295 ST-Segment Elevation Myocardial Infarction
    Elliott M. Antman, Joseph Loscalzo

296e Percutaneous Coronary interventions and other interventional Procedures
    David P. Faxon, Deepak L. Bhatt

297e Atlas of Percutaneous Revascularization
    Jane A. Leopold, Deepak L. Bhatt, David P. Faxon

298 Hypertensivevascular Disease
    Theodore A. Kotchen

299 Renovascular Disease
    Stephen C. Textor

300 Deep Venous Thrombosis and Pulmonary Thromboembolism
    Samuel Z. Goldhaber

301 Diseases of the Aorta
    Mark A. Creager, Joseph Loscalzo

302 Arterial Diseases of the Extremities
    Mark A. Creager, Joseph Loscalzo

303 Chronic Venous Disease and Lymphedema
    Mark A. Creager, Joseph Loscalzo

304 Pulmonary Hypertension
    Aaron B. Waxman, Joseph Loscalzo

Part 11 Disorders of the Respiratory System
Section 1 Diagnosis of Respiratory Disorders
305 Approach to the Patient with Disease of the Respiratory System
    Patricia A. Kritek, Augustine M. K. Choi

306e Disturbances of Respiratory Function
    Edward T. Naureckas, Julian Solway

307 Diagnostic Procedures in Respiratory Disease
    Anne L. Fuhlbrigge, Augustine M. K. Choi

308e Atlas of Chest Imaging
    Patricia A. Kritek, John J. Reilly, Jr.

Section 2 Diseases of the Respiratory System
309 Asthma
    Peter J. Barnes

310 Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia
    Praveen Akuthota, Michael E. Wechsler

311 Occupational and Environmental Lung Disease
    John R. Balmes, Frank E. Speizer

312 Bronchiectasis
    Rebecca M. Baron, Miriam Baron Barshak

313 Cysticfibrosis
    Eric J. Sorscher

314 Chronic Obstructive Pulmonary Disease
    John J. Reilly, Jr., Edwin K. Silverman, Steven D. Shapiro

315 Interstitial Lung Diseases
    Talmadge E. King, Jr.

316 Disorders of the Pleura
    Richard W. Light

317 Disorders of the Mediastinum
    Richard W. Light

318 Disorders of Ventilation
    John F. McConville, Babak Mokhlesi, Julian Solway

319 Sleep Apnea
    Andrew Wellman, Susan Redline

320e Lung Transplantation
    Elbert P. Trulock

Part 12 Critical Care Medicine
Section 1 Respiratory Critical Care
321 Approach to the Patient with Critical Illness
    John P. Kress, Jesse B. Hall

322 Acute Respiratory Distress Syndrome
    Bruce D. Levy, Augustine M. K. Choi

323 Mechanical Ventilatory Support
    Bartolome R. Celli

Section 2 Shock and Cardiac Arrest
324 Approach to the Patient with Shock
    Ronald V. Maier

325 Severe Sepsis and Septic Shock
    Robert S. Munford

326 Cardiogenic Shock and Pulmonary Edema
    Judith S. Hochman, David H. Ingbar

327 Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death
    Robert J. Myerburg, Agustin Castellanos

Section 3 Neurologic Critical Care
328 Coma
    Allan H. Ropper

329e Examination of the Comatose Patient
    S. Andrew Josephson

330 Neurologic Critical Care, including Hypoxic-ischemic Encephalopathy, and Subarachnoid Hemorrhage
    J. Claude Hemphill, III, Wade S. Smith, Daryl R. Gress

Section 4 Oncologic Emergencies
331 Oncologic Emergencies
    Rasim Gucalp, Janice P. Dutcher

Part 13 Disorders of the Kidney and Urinary Tract
Disorders of the Kidney and Urinary Tract
332e Cellular and Molecular Biology of the Kidney
    Alfred L. George, Jr., Eric G. Neilson

333e Adaptation of the Kidney to Injury
    Joseph V. Bonventre

334 Acute Kidney Injury
    Sushrut S. Waikar, Joseph V. Bonventre

335 Chronic Kidney Disease
    Joanne M. Bargman, Karl Skorecki

336 Dialysis in the Treatment of Renal Failure
    Kathleen D. Liu, Glenn M. Chertow

337 Transplantation in the Treatment of Renal Failure
    Jamil Azzi, Edgar L. Milford, Mohamed H. Sayegh, Anil Chandraker

338 Glomerular Diseases
    Julia B. Lewis, Eric G. Neilson

339 Polycystic Kidney Disease and other Inherited Disorders of Tubule Growth and Development
    Jing Zhou, Martin R. Pollak

340 Tubulointerstitial Diseases of the Kidney
    Laurence H. Beck, David J. Salant

341 Vascular Injury to the Kidney
    Nelson Leung, Stephen C. Textor

342 Nephrolithiasis
    Gary C. Curhan

343 Urinary Tract Obstruction
    Julian L. Seifter

Part 14 Disorders of the Gastrointestinal System
Section 1 Disorders of the Alimentary Tract
344 Approach to the Patient with Gastrointestinal Disease
    William L. Hasler, Chung Owyang

345 Gastrointestinal Endoscopy
    Louis Michel Wong Kee Song, Mark Topazian

346e Video Atlas of Gastrointestinal Endoscopy
    Louis Michel Wong Kee Song, Mark Topazian

347 Diseases of the Esophagus
    Peter J. Kahrilas, Ikuo Hirano

348 Peptic Ulcer Disease and Related Disorders
    John Del Valle

349 Disorders of Absorption
    Henry J. Binder

350e The Schilling Test
    Henry J. Binder

351 Inflammatory Bowel Disease
    Sonia Friedman, Richard S. Blumberg

352 Irritable Bowel Syndrome
    Chung Owyang

353 Diverticular Disease and Common Anorectal Disorders
    Rizwan Ahmed, Susan L. Gearhart

354 Mesentericvascularinsufficiency
    Rizwan Ahmed, Mahmoud Malas

355 Acute Intestinal Obstruction
    Danny O. Jacobs

356 Acute Appendicitis and Peritonitis
    Danny O. Jacobs

Section 2 Liver and Biliary Tract Disease
357 Approach to the Patient with Liver Disease
    Marc G. Ghany, Jay H. Hoofnagle

358 Evaluation of Liver Function
    Daniel S. Pratt

359 The Hyperbilirubinemias
    Allan W. Wolkoff

360 Acute Viral Hepatitis
    Jules L. Dienstag

361 Toxic and Drug-induced Hepatitis
    William M. Lee, Jules L. Dienstag

362 Chronic Hepatitis
    Jules L. Dienstag

363 Alcoholic Liver Disease
    Mark E. Mailliard, Michael F. Sorrell

364 Nonalcoholic Fatty Liver Diseases and Nonalcoholic Tteatohepatitis
    Manal F. Abdelmalek, Anna Mae Diehl

365 Cirrhosis and Its Complications
    Bruce R. Bacon

366e Atlas of Liver Biopsies
    Jules L. Dienstag, Atul K. Bhan

367e Genetic, Metabolic, and Infiltrative Diseases Affecting the Liver
    Bruce R. Bacon

368 Liver Transplantation
    Raymond T. Chung, Jules L. Dienstag

369 Diseases of the Gallbladder and Bile Ducts
    Norton J. Greenberger, Gustav Paumgartner

Section 3 Disorders of the Pancreas
370 Approach to the Patient with Pancreatic Disease
    Darwin L. Conwell, Norton J. Greenberger, Peter A. Banks

371 Acute and Chronic Pancreatitis
    Darwin L. Conwell, Peter A. Banks, Norton J. Greenberger

Part 15 Immune-Mediated, inflammatory, and Rheumatologic Disorders
Section 1 The Immune System in Health and Disease
372e Introduction to the Immune System
    Barton F. Haynes, Kelly A. Soderberg, Anthony S. Fauci

373e the Major Histocompatibility Complex
    Gerald T. Nepom

374 Primary Immune Deficiency Diseases
    Alain Fischer

375e Primary Immunodeficiencies Associated with (or secondary to) Other Diseases
    Alain Fischer

Section 2 Disorders of Immune-Mediated Injury
376 Allergies, Anaphylaxis, and Systemic Mastocytosis
    Joshua A. Boyce, K. Frank Austen

377e Autoimmunity and Autoimmune Diseases
    Betty Diamond, Peter E. Lipsky

378 Systemic Lupus Erythematosus
    Bevra Hannahs Hahn

379 Antiphospholipid Syndrome
    Haralampos M. Moutsopoulos, Panayiotis G. Vlachoyiannopoulos

380 Rheumatoid Arthritis
    Ankoor Shah, E. William St. Clair

381 Acuterheumatic Fever
    Jonathan R. Carapetis

382 Systemic Sclerosis (Scleroderma) and Related Disorders
    John Varga

383 Sjögren’s Syndrome
    Haralampos M. Moutsopoulos, Athanasios G. Tzioufas

384 The Spondyloarthritides
    Joel D. Taurog, John D. Carter

385 The Vasculitis Syndromes
    Carol A. Langford, Anthony S. Fauci

386e Atlas of the Vasculitic Syndromes
    Carol A. Langford, Anthony S. Fauci

387 Behçet’s Syndrome
    Haralampos M. Moutsopoulos

388 Polymyositis, Dermatomyositis, and Inclusion Body Myositis
    Marinos C. Dalakas

389 Relapsing Polychondritis
    Carol A. Langford

390 Sarcoidosis
    Robert P. Baughman, Elyse E. Lower

391e IgG4-Related Disease
    John H. Stone

392 Familial Mediterranean Fever and Other Hereditary Autoinflammatory Diseases
    Daniel L. Kastner

Section 3 Disorders of the Joints and Adjacent Tissues
393 Approach to Articular and Musculoskeletal Disorders
    John J. Cush

394 Osteoarthritis
    David T. Felson

395 Gout and Other Crystal-Associated Arthropathies
    H. Ralph Schumacher, Lan X. Chen

396 Fibromyalgia
    Leslie J. Crofford

397 Arthritis Associated with Systemic Disease, and Other Arthritides
    Carol A. Langford, Brian F. Mandell

398 Periarticular Disorders of the Extremities
    Carol A. Langford

Part 16 Endocrinology and Metabolism
Section 1 Endocrinology
399 Approach to the Patient with Endocrine Disorders
    J. Larry Jameson

400e Mechanisms of Hormone Action
    J. Larry Jameson

401e Anterior Pituitary: Physiology of Pituitary Hormones
    Shlomo Melmed, J. Larry Jameson

402 Hypopituitarism
    Shlomo Melmed, J. Larry Jameson

403 Anterior Pituitary Tumor Syndromes
    Shlomo Melmed, J. Larry Jameson

404 disorders of the Neurohypophysis
    Gary L. Robertson

405 Disorders of the Thyroid Gland
    J. Larry Jameson, Susan J. Mandel, Anthony P. Weetman

406 Disorders of the Adrenal Cortex
    Wiebke Arlt

407 Pheochromocytoma
    Hartmut P. H. Neumann

408 Multiple Endocrine Neoplasia
    Rajesh V. Thakker

409 Autoimmune Polyendocrine Syndromes
    Peter A. Gottlieb

Section 2 Reproductive Endocrinology
410 Disorders of Sex Development
    John C. Achermann, J. Larry Jameson

411 Disorders of the Testes and Male Reproductive System
    Shalender Bhasin, J. Larry Jameson

412 Disorders of the Female Reproductive System
    Janet E. Hall

413 Menopause and Postmenopausal Hormone Therapy
    JoAnn E. Manson, Shari S. Bassuk

414 Infertility and Contraception
    Janet E. Hall

Section 3 Obesity, Diabetes Mellitus, and Metabolic Syndrome
415e Biology of Obesity
    Jeffrey S. Flier, Eleftheria Maratos-Flier

416 Evaluation and Management of Obesity
    Robert F. Kushner

417 Diabetes Mellitus: Diagnosis, Classification, and Pathophysiology
    Alvin C. Powers

418 Diabetes Mellitus: Management and Therapies
    Alvin C. Powers

419 Diabetes Mellitus: Complications
    Alvin C. Powers

420 Hypoglycemia
    Philip E. Cryer, Stephen N. Davis

421 Disorders of Lipoprotein Metabolism
    Daniel J. Rader, Helen H. Hobbs

422 The Metabolic Syndrome
    Robert H. Eckel

Section 4 Disorders of Bone and Mineral Metabolism
423 Bone and Mineral Metabolism in Health and Disease
    F. Richard Bringhurst, Marie B. Demay, Stephen M. Krane, Henry M. Kronenberg

424 Disorders of the Parathyroid Gland and Calcium Homeostasis
    John T. Potts, Jr., Harald Jüppner

425 Osteoporosis
    Robert Lindsay, Felicia Cosman

426e Paget's Disease and Other Dysplasias of Bone
    Murray J. Favus, Tamara J. Vokes

Section 5 Disorders of Intermediary Metabolism
427 Heritable Disorders of Connective Tissue
    Darwin J. Prockop, John F. Bateman

428 Hemochromatosis
    Lawrie W. Powell

429 Wilson’s Disease
    George J. Brewer

430 The Porphyrias
    Robert J. Desnick, Manisha Balwani

431e Disorders of Purine and Pyrimidine Metabolism
    Christopher M. Burns, Robert L. Wortmann

432e Lysosomal Storage Diseases
    Robert J. Hopkin, Gregory A. Grabowski

433e Glycogen Storage Diseases and other Inherited Disorders of Carbohydrate Metabolism
    Priya S. Kishnani, Yuan-Tsong Chen

434e Inherited Disorders of Amino Acid Metabolism in Adults
    Nicola Longo

435e Inherited Defects of Membrane Transport
    Nicola Longo

436e Atlas of Clinical Manifestations of Metabolic Diseases
    J. Larry Jameson

Part 17 Neurologic Disorders
Section 1 Diagnosis of Neurologic Disorders
437 Approach to the Patient with Neurologic Disease
    Daniel H. Lowenstein, Joseph B. Martin, Stephen L. Hauser

438e The Neurologic Screening Exam
    Daniel H. Lowenstein

439e Video Atlas of the Detailed Neurologic Examination
    Martin A. Samuels

440e Neuroimaging in Neurologic Disorders
    William P. Dillon

441e Atlas of Neuroimaging
    Andre D. Furtado, William P. Dillon

442e Electrodiagnostic Studies of Nervous System Disorders: EEG, Evoked Potentials, and EMG
    Michael J. Aminoff

443e technique of Lumbar Puncture
    Elizabeth Robbins, Stephen L. Hauser

444e Biology of Neurologic Diseases
    Stephen L. Hauser, Stanley B. Prusiner, M. Flint Beal

Section 2 Diseases of the Central Nervous System
445 Seizures and Epilepsy
    Daniel H. Lowenstein

446 Cerebrovasculardiseases
    Wade S. Smith, S. Claiborne Johnston, J. Claude Hemphill, III

447 Migraine and Other Primary Headache Disorders
    Peter J. Goadsby, Neil H. Raskin

448 Alzheimer’s Disease and Other Dementias
    William W. Seeley, Bruce L. Miller

449 Parkinson’s Disease and other Movement Disorders
    C. Warren Olanow, Anthony H.V. Schapira, Jose A. Obeso

450 Ataxicdisorders
    Roger N. Rosenberg

451e Classification of the Spinocerebellar Ataxias
    Roger N. Rosenberg

452 Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases
    Robert H. Brown, Jr.

453e Prion Diseases
    Stanley B. Prusiner, Bruce L. Miller

454 Disorders of the Autonomic Nervous System
    Phillip A. Low, John W. Engstrom

455 Trigeminal Neuralgia, Bell’s Palsy, and Other Cranial Nerve Disorders
    M. Flint Beal, Stephen L. Hauser

456 Diseases of the Spinal Cord
    Stephen L. Hauser, Allan H. Ropper

457e Concussion and other Traumatic Brain Injuries
    Allan H. Ropper

458 Multiple Sclerosis and Other Demyelinating Diseases
    Stephen L. Hauser, Douglas S. Goodin

Section 3 Nerve and Muscle Disorders
459 Peripheral Neuropathy
    Anthony A. Amato, Richard J. Barohn

460 Guillain-Barré Syndrome and Other Immune-Mediated Neuropathies
    Stephen L. Hauser, Anthony A. Amato

461 Myasthenia Gravis and Other Diseases of the Neuromuscular Junction
    Daniel B. Drachman, Anthony A. Amato

462e Muscular Dystrophies and Other Muscle Diseases
    Anthony A. Amato, Robert H. Brown, Jr.

463e Special Issues in Inpatient Neurologic Consultation
    S. Andrew Josephson, Martin A. Samuels

Section 4 Chronic Fatigue Syndrome
464e Chronic Fatigue Syndrome
    Gijs Bleijenberg, Jos W. M. van der Meer

Section 5 Psychiatric and Addiction Disorders
465e Biology of Psychiatric Disorders
    Robert O. Messing, Eric J. Nestler

466 Mental Disorders
    Victor I. Reus

467 Alcohol and Alcoholism
    Marc A. Schuckit

468e Opioid-related Disorders
    Thomas R. Kosten, Colin N. Haile

469e Cocaine and Other Commonly Abused Drugs
    Nancy K. Mello, Jack H. Mendelson

470 Nicotine Addiction
    David M. Burns

471e Neuropsychiatric Illnesses in War Veterans
    Charles W. Hoge

Part 18 Poisoning, Drug Overdose, and Envenomation
Poisoning, Drug Overdose, and Envenomation
472e Heavy Metal Poisoning
    Howard Hu

473e Poisoning and drug overdose
    Mark B. Mycyk

474 Disorders Caused by Venomous Snakebites and Marine Animal Exposures
    Charles Lei, Natalie J. Badowski, Paul S. Auerbach, Robert L. Norris

475 Ectoparasite Infestations and Arthropod Injuries
    Richard J. Pollack, Scott A. Norton

Part 19 Disorders Associated with Environmental Exposures
Disorders Associated with Environmental Exposures
476e Altitude Illness
    Buddha Basnyat, Geoffrey Tabin

477e Hyperbaric and Diving Medicine
    Michael H. Bennett, Simon J. Mitchell

478e Hypothermia and Frostbite
    Daniel F. Danzl

479e Heat-related Illnesses
    Daniel F. Danzl

Appendix: Laboratory Values of Clinical Importance
    Alexander Kratz, Michael A. Pesce, Robert C. Basner, Andrew J. Einstein

480e The Clinical Laboratory in Modern Health Care
    Anthony A. Killeen

481e Clinical Procedure Tutorial: Central Venous Catheter Placement
    Maria A. Yialamas, William E. Corcoran, Gyorgy Frendl, Kurt Fink

482e Clinical Procedure Tutorial: Thoracentesis
    Charles A. Morris, Andrea S. Wolf

483e Clinical Procedure Tutorial: Abdominal Paracentesis
    Maria A. Yialamas, Anna E. Rutherford, Lindsay King

484e Clinical Procedure Tutorial: Endotracheal Intubation
    Charles A. Morris, Emily Page Nelson

485e Clinical Procedures Tutorial: Percutaneous Arterial Blood Gas Sampling
    Christian D. Becker
    Medical Editors: Sean Sadikot, Jeremy Matloff

486e Clinical Procedures Tutorial: Lumbar Puncture
    Beth Rapaport, Stephen Krieger, Corey McGraw
    Medical Editors: Sean Sadikot, Jeremy Matloff

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