Preface
Table of Contents
(click on a section heading to view contents)
Part 1 General Considerations in Clinical Medicine
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General Considerations in Clinical Medicine
1 The Practice of Medicine
The Editors 2 Global Issues in Medicine Paul Farmer, Joseph Rhatigan 3 Decision-Making in Clinical Medicine Daniel B. Mark, John B. Wong 4 Screening and Prevention of Disease Katrina Armstrong, Gary J. Martin 5 Principles of Clinical Pharmacology Dan M. Roden 6e Women’s Health Andrea Dunaif 7e Men’s Health Shalender Bhasin, Shehzad Basaria 8 Medical Disorders During Pregnancy Robert L. Barbieri, John T. Repke 9 Medical Evaluation of the Surgical Patient Wei C. Lau, Kim A. Eagle 10 Palliative and End-of-Life Care Ezekiel J. Emanuel 11 Clinical Problems of Aging Luigi Ferrucci, Stephanie Studenski 12e The Safety and Quality of Health Care David W. Bates 13e Primary Care in Low- and Middle-income Countries Tim Evans, Kumanan Rasanathan 14e Complementary, Alternative, and Integrative Health Practices Josephine P. Briggs 15e The Economics of Medical Care Joseph P. Newhouse 16e Racial and Ethnic disparities in Health Care Joseph R. Betancourt, Alexander R. Green 17e Ethical issues in Clinical Medicine Bernard Lo, Christine Grady |
Part 2 Cardinal Manifestations and Presentation of Diseases
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Section 1 Pain
18 Pain: Pathophysiology and Management
James P. Rathmell, Howard L. Fields 19 Chestdiscomfort David A. Morrow 20 Abdominal Pain Danny O. Jacobs, William Silen 21 Headache Peter J. Goadsby, Neil H. Raskin 22 Back and Neck Pain John W. Engstrom, Richard A. Deyo |
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Section 2 Alterations in Body Temperature
23 Fever
Charles A. Dinarello, Reuven Porat 24 Fever and Rash Elaine T. Kaye, Kenneth M. Kaye 25e Atlas of Rashes Associated with Fever Kenneth M. Kaye, Elaine T. Kaye 26 Fever of Unknown Origin Chantal P. Bleeker-Rovers, Jos W. M. van der Meer |
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Section 3 Nervous System Dysfunction
27 Syncope
Roy Freeman 28 Dizziness and Vertigo Mark F. Walker, Robert B. Daroff 29 Fatigue Jeffrey M. Gelfand, Vanja C. Douglas 30 Neurologic Causes of Weakness and Paralysis Michael J. Aminoff 31 Numbness, Tingling, and Sensory Loss Michael J. Aminoff 32 Gait and Balance Disorders Lewis Sudarsky 33e video Library of Gait Disorders Gail Kang, Nicholas B. Galifianakis, Michael D. Geschwind 34 Confusion and Delirium S. Andrew Josephson, Bruce L. Miller 35 Dementia William W. Seeley, Bruce L. Miller 36 Aphasia, Memory Loss, and other focal Cerebraldisorders M.-Marsel Mesulam 37e Primary Progressive Aphasia, Memory Loss, and Other Focal Cerebral Disorders Maria Luisa Gorno-Tempini, Jennifer Ogar, Joel Kramer, Bruce L. Miller, Gil Rabinovici, Maria Carmela Tartaglia 38 Sleepdisorders Charles A. Czeisler, Thomas E. Scammell, Clifford B. Saper |
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Section 4 Disorders of Eyes, Ears, Nose, and Throat
39 Disorders of the Eye
Jonathan C. Horton 40e Use of the Hand-Held Ophthalmoscope Homayoun Tabandeh, Morton F. Goldberg 41e Video Library of Neuro-ophthalmology Shirley H. Wray 42 Disorders of Smell and Taste Richard L. Doty, Steven M. Bromley 43 Disorders of Hearing Anil K. Lalwani 44 Sore Throat, Earache, and Upper Respiratory Symptoms Michael A. Rubin, Larry C. Ford, Ralph Gonzales 45 Oral Manifestations of Disease Samuel C. Durso 46e Atlas of Oral Manifestations of Disease Samuel C. Durso, Janet A. Yellowitz |
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Section 5 Alterations in Circulatory and Respiratory Functions
47e Dyspnea
Richard M. Schwartzstein 48 Cough and Hemoptysis Patricia A. Kritek, Christopher H. Fanta 49 Hypoxia and Cyanosis Joseph Loscalzo 50 Edema Eugene Braunwald, Joseph Loscalzo 51e Approach to the Patient with a Heart Murmur Patrick T. O’Gara, Joseph Loscalzo 52 Palpitations Joseph Loscalzo |
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Section 6 Alterations in Gastrointestinal Function
53 Dysphagia
Ikuo Hirano, Peter J. Kahrilas 54 Nausea, Vomiting, and Indigestion William L. Hasler 55 Diarrhea and Constipation Michael Camilleri, Joseph A. Murray 56 involuntary Weight Loss Russell G. Robertson, J. Larry Jameson 57 Gastrointestinal Bleeding Loren Laine 58 Jaundice Savio John, Daniel S. Pratt 59 Abdominal Swelling and Ascites Kathleen E. Corey, Lawrence S. Friedman |
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Section 7 Alterations in Renal and Urinary Tract Function
60e Dysuria, Bladder Pain, and the interstitial Cystitis/Bladder Pain Syndrome
John W. Warren 61 Azotemia and urinary Abnormalities Julie Lin, Bradley M. Denker 62e Atlas of Urinary Sediments and Renal Biopsies Agnes B. Fogo, Eric G. Neilson 63 Fluid and Electrolyte Disturbances David B. Mount 64e Fluid and Electrolyte imbalances and Acid-Base Disturbances: Case Examples David B. Mount, Thomas D. DuBose, Jr. 65 Hypercalcemia and Hypocalcemia Sundeep Khosla 66 Acidosis and Alkalosis Thomas D. DuBose, Jr. |
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Section 8 Alterations in Sexual Function and Reproduction
67 Sexual Dysfunction
Kevin T. McVary 68 Hirsutism David A. Ehrmann 69 Menstrual Disorders and Pelvic Pain Janet E. Hall |
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Section 9 Alterations in the Skin
70 Approach to the Patient with a Skin Disorder
Thomas J. Lawley, Kim B. Yancey 71 Eczema, Psoriasis, Cutaneous infections, Acne, and other Common Skin Disorders Leslie P. Lawley, Calvin O. McCall, Thomas J. Lawley 72 Skin Manifestations of Internal Disease Jean L. Bolognia, Irwin M. Braverman 73 Immunologically Mediated Skin Diseases Kim B. Yancey, Thomas J. Lawley 74 Cutaneous Drug Reactions Kanade Shinkai, Robert S. Stern, Bruce U. Wintroub 75 Photosensitivity and Other Reactions to Light Alexander G. Marneros, David R. Bickers 76e Atlas of Skin Manifestations of Internaldisease Thomas J. Lawley, Calvin O. McCall, Robert A. Swerlick |
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Section 10 Hematologic Alterations
77 Anemia and Polycythemia
John W. Adamson, Dan L. Longo 78 Bleeding and Thrombosis Barbara A. Konkle 79 Enlargement of Lymph Nodes and Spleen Patrick H. Henry, Dan L. Longo 80 Disorders of Granulocytes and Monocytes Steven M. Holland, John I. Gallin 81e Atlas of Hematology and Analysis of Peripheral Blood Smears Dan L. Longo |
Part 3 Genes, the Environment, and Disease
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Genes, the Environment, and Disease
82 Principles of Human Genetics
J. Larry Jameson, Peter Kopp 83e Chromosomedisorders Nancy B. Spinner, Laura K. Conlin 84 The Practice of Genetics in Clinical Medicine Susan M. Domchek, J. Larry Jameson, Susan Miesfeldt 85e Mitochondrial DNA and Heritable Traits and Diseases Karl Skorecki, Doron Behar 86e The Human Microbiome Jeffrey I. Gordon, Rob Knight 87e Network Medicine: Systems Biology in Health and Disease Joseph Loscalzo |
Part 4 Regenerative Medicine
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Regenerative Medicine
88 Stem Cell Biology
Minoru S. H. Ko 89e Hematopoietic Stem Cells David T. Scadden, Dan L. Longo 90e Applications of Stem Cell Biology in Clinical Medicine John A. Kessler 91e Gene Therapy in Clinical Medicine Katherine A. High 92e Tissue Engineering Anthony Atala |
Part 5 Aging
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Aging
93e World Demography of Aging
Richard M. Suzman, John G. Haaga 94e The Biology of Aging Rafael de Cabo, David G. Le Couteur |
Part 6 Nutrition and Weight Loss
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Nutrition and Weight Loss
95e Nutrient Requirements and Dietary Assessment
Johanna Dwyer 96e vitamin and trace Mineral Deficiency and Excess Robert M. Russell, Paolo M. Suter 97 Malnutrition and Nutritional Assessment Douglas C. Heimburger 98e Enteral and Parenteral Nutrition Therapy Bruce R. Bistrian, L. John Hoffer, David F. Driscoll |
Part 7 Oncology and Hematology
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Section 1 Neoplastic Disorders
99 Approach to the Patient with Cancer
Dan L. Longo 100 Prevention and Early detection of Cancer Jennifer M. Croswell, Otis W. Brawley, Barnett S. Kramer 101e Cancer Genetics Pat J. Morin, Jeffrey M. Trent, Francis S. Collins, Bert Vogelstein 102e Cancer Cell Biology Jeffrey W. Clark, Dan L. Longo 103e Principles of Cancer treatment Edward A. Sausville, Dan L. Longo 104 infections in Patients with Cancer Robert W. Finberg 105 Cancer of the skin Walter J. Urba, Brendan D. Curti 106 Head and neck Cancer Everett E. Vokes 107 Neoplasms of the Lung Leora Horn, Christine M. Lovly, David H. Johnson 108 Breast Cancer Marc E. Lippman 109 Upper Gastrointestinal tract Cancers Robert J. Mayer 110 Lower Gastrointestinal Cancers Robert J. Mayer 111 Tumors of the Liver and Biliary Tree Brian I. Carr 112 Pancreatic Cancer Elizabeth Smyth, David Cunningham 113 Endocrine tumors of the Gastrointestinal Tract and Pancreas Robert T. Jensen 114 Bladder and Renal Cell Carcinomas Howard I. Scher, Jonathan E. Rosenberg, Robert J. Motzer 115 Benign and Malignant Diseases of the Prostate Howard I. Scher, James A. Eastham 116 Testicular Cancer Robert J. Motzer, Darren R. Feldman, George J. Bosl 117 Gynecologic Malignancies Michael V. Seiden 118 Primary and Metastatic Tumors of the Nervous System Lisa M. DeAngelis, Patrick Y. Wen 119e Soft Tissue and Bone Sarcomas andvBone Metastases Shreyaskumar R. Patel, Robert S. Benjamin 120e Carcinoma of Unknown Primary Gauri R. Varadhachary, James L. Abbruzzese 121 Paraneoplastic Syndromes: Endocrinologic/Hematologic J. Larry Jameson, Dan L. Longo 122 Paraneoplastic neurologic syndromes and Autoimmune Encephalitis Josep Dalmau, Myrna R. Rosenfeld 123e Thymoma Dan L. Longo 124e Neoplasia During Pregnancy Michael F. Greene, Dan L. Longo 125 Late Consequences of Cancer and its Treatment Carl E. Freter, Dan L. Longo |
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Section 2 Hematopoietic Disorders
126 Iron Deficiency and Other Hypoproliferative Anemias
John W. Adamson 127 Disorders of Hemoglobin Edward J. Benz, Jr. 128 Megaloblastic Anemias A. Victor Hoffbrand 129 Hemolytic Anemias and Anemia Due to Acute Blood Loss Lucio Luzzatto 130 Bone Marrow Failure Syndromes Including Aplastic Anemia and Myelodysplasia Neal S. Young 131 Polycythemia Vera and Other Myeloproliferative Neoplasms Jerry L. Spivak 132 Acute Myeloid Leukemia Guido Marcucci, Clara D. Bloomfield 133 Chronic Myeloid Leukemia Hagop Kantarjian, Jorge Cortes 134 Malignancies of Lymphoid Cells Dan L. Longo 135e Less Common Hematologic Malignancies Ayalew Tefferi, Dan L. Longo 136 Plasma Cell Disorders Nikhil C. Munshi, Dan L. Longo, Kenneth C. Anderson 137 Amyloidosis David C. Seldin, John L. Berk 138e Transfusion Biology and Therapy Jeffery S. Dzieczkowski, Kenneth C. Anderson 139e Hematopoietic Cell Transplantation Frederick R. Appelbaum |
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Section 3 Disorders of Hemostasis
140 Disorders of Platelets and Vessel Wall
Barbara A. Konkle 141 Coagulation Disorders Valder R. Arruda, Katherine A. High 142 Arterial and Venous Thrombosis Jane E. Freedman, Joseph Loscalzo 143 Antiplatelet, Anticoagulant, and Fibrinolytic Drugs Jeffrey I. Weitz |
Part 8 Infectious Diseases
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Section 1 Basic Considerations in Infectious Diseases
144 Approach to the Patient with an infectiousdisease
Neeraj K. Surana, Dennis L. Kasper 145e Molecular Mechanisms of Microbial Pathogenesis Gerald B. Pier 146 Genomics and Infectious Disease Roby P. Bhattacharyya, Yonatan H. Grad, Deborah T. Hung 147 Approach to the Acutely Ill Infected Febrile Patient Tamar F. Barlam, Dennis L. Kasper 148 Immunization Principles and Vaccine Use Anne Schuchat, Lisa A. Jackson 149 Health Recommendations for International Travel Jay S. Keystone, Phyllis E. Kozarsky 150e Laboratory Diagnosis of Infectious Diseases Alexander J. McAdam, Andrew B. Onderdonk 151e Climate Change and Infectious Disease Aaron S. Bernstein 152e Infections in Veterans Returning from Foreign Wars Andrew W. Artenstein |
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Section 2 Clinical Syndromes: Community-Acquired Infections
153 Pneumonia
Lionel A. Mandell, Richard G. Wunderink 154 Lung Abscess Rebecca M. Baron, Miriam Baron Barshak 155 Infective Endocarditis Adolf W. Karchmer 156 Infections of the skin, Muscles, and Soft Tissues Dennis L. Stevens 157 Infectious Arthritis Lawrence C. Madoff 158 osteomyelitis Werner Zimmerli 159 Intraabdominal Infections and Abscesses Miriam Baron Barshak, Dennis L. Kasper 160 Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning Regina C. LaRocque, Edward T. Ryan, Stephen B. Calderwood 161 Clostridium Difficile Infection, Including Pseudomembranous Colitis Dale N. Gerding, Stuart Johnson 162 Urinary Tract Infections, Pyelonephritis, and Prostatitis Kalpana Gupta, Barbara W. Trautner 163 Sexually transmitted infections: Overview and Clinical Approach Jeanne M. Marrazzo, King K. Holmes 164 Meningitis, Encephalitis, Brain Abscess, and Empyema Karen L. Roos, Kenneth L. Tyler 165 Chronic and recurrent Meningitis Walter J. Koroshetz, Avindra Nath 166e Infectious Complications of Burns Lawrence C. Madoff, Florencia Pereyra 167e Infectious Complications of Bites Lawrence C. Madoff, Florencia Pereyra |
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Section 3 Clinical Syndromes: Health Care–associated Infections
168 Infections Acquired in Health Care Facilities
Robert A. Weinstein 169 Infections in Transplant Recipients Robert W. Finberg, Joyce Fingeroth |
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Section 4 Approach to Therapy for Bacterial Diseases
170 Treatment and Prophylaxis of Bacterial Infections
David C. Hooper, Erica S. Shenoy, Christy A. Varughese |
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Section 5 Diseases Caused By Gram-Positive Bacteria
171 Pneumococcal Infections
David Goldblatt, Katherine L. O’Brien 172 Staphylococcal Infections Franklin D. Lowy 173 Streptococcal Infections Michael R. Wessels 174 Enterococcal Infections Cesar A. Arias, Barbara E. Murray 175 Diphtheria and other Corynebacterial Infections William R. Bishai, John R. Murphy 176 Listeria Monocytogenes Infections Elizabeth L. Hohmann, Daniel A. Portnoy 177 Tetanus C. Louise Thwaites, Lam Minh Yen 178 Botulism Susan Maslanka, Agam K. Rao 179 Gas Gangrene and Other Clostridial Infections Amy E. Bryant, Dennis L. Stevens |
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Section 6 Diseases Caused By Gram-negative Bacteria
180 Meningococcalinfections
Andrew J. Pollard 181 Gonococcal Infections. Sanjay Ram, Peter A. Rice 182 HaemophilusandMoraxella Infections Timothy F. Murphy 183e Infections due to the HACEK Group and Miscellaneous Gram-negative Bacteria Tamar F. Barlam, Dennis L. Kasper 184 Legionellainfections Victor L. Yu, M. Luisa Pedro-Botet, Yusen E. Lin 185 Pertussis and other Bordetella iInfections Karina A. Top, Scott A. Halperin 186 Diseases Caused by Gram-negative Enteric Bacilli Thomas A. Russo, James R. Johnson 187 Acinetobacter Infections David L. Paterson, Anton Y. Peleg 188 Helicobacter Pylori Infections John C. Atherton, Martin J. Blaser 189 Infections Due to Pseudomonas species and Related Organisms Reuben Ramphal 190 Salmonellosis David A. Pegues, Samuel I. Miller 191 Shigellosis Philippe J. Sansonetti, Jean Bergounioux 192 infections Due to Campylobacter and Related Organisms Martin J. Blaser 193 Cholera and Other Vibrioses Matthew K. Waldor, Edward T. Ryan 194e Brucellosis Nicholas J. Beeching, Michael J. Corbel 195 Tularemia Richard F. Jacobs, Gordon E. Schutze 196 Plague and other Yersinia Infections Michael B. Prentice 197 Bartonella Infections, Including Cat-scratch Disease Michael Giladi, Moshe Ephros 198e Donovanosis Nigel O’Farrell |
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Section 7 Miscellaneous Bacterial Infections
199 Nocardiosis
Gregory A. Filice 200 Actinomycosis and Whipple’s Disease Thomas A. Russo 201 Infections Due to Mixed Anaerobic Organisms Ronit Cohen-Poradosu, Dennis L. Kasper |
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Section 8 Mycobacterial Diseases
202 Tuberculosis
Mario C. Raviglione 203 Leprosy Robert H. Gelber 204 Nontuberculous Mycobacterial Infections Steven M. Holland 205e Antimycobacterial Agents Max R. O’Donnell, Divya Reddy, Jussi J. Saukkonen |
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Section 9 Spirochetal Diseases
206 Syphilis
Sheila A. Lukehart 207e Endemic Treponematoses Sheila A. Lukehart 208 Leptospirosis Rudy A. Hartskeerl, Jiři F. P. Wagenaar 209 Relapsing Fever Alan G. Barbour 210 Lyme Borreliosis Allen C. Steere |
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Section 10 Diseases Caused By Rickettsiae, Mycoplasmas, and Chlamydiae
211 Rickettsial Diseases
David H. Walker, J. Stephen Dumler, Thomas Marrie 212 infections Due to Mycoplasmas R. Doug Hardy 213 Chlamydial Infections Charlotte A. Gaydos, Thomas C. Quinn |
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Section 11 Viral Diseases: General Considerations
214e Medicalvirology
Fred Wang, Elliott Kieff 215e Antiviral Chemotherapy, Excluding Antiretroviral Drugs Lindsey R. Baden, Raphael Dolin |
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Section 12 Infections Due to DNA Viruses
216 Herpes Simplex Virus Infections
Lawrence Corey 217 Varicella-Zoster Virus Infections Richard J. Whitley 218 Epstein-Barr Virus Infections, including Infectious Mononucleosis Jeffrey I. Cohen 219 Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8 Camille Nelson Kotton, Martin S. Hirsch 220e Molluscum Contagiosum, Monkeypox, and other Poxvirus Infections Fred Wang 221 Parvovirus Infections Kevin E. Brown 222 Human Papillomavirus Infections Aaron C. Ermel, Darron R. Brown |
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Section 13 Infections Due to DNA and RNA Respiratory Viruses
223 Common Viral Respiratory Infections
Raphael Dolin 224 Influenza Yehuda Z. Cohen, Raphael Dolin |
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Section 14 Infections Due to Human Immunodeficiency Virus and other Human Retroviruses
225e The Human Retroviruses
Dan L. Longo, Anthony S. Fauci 226 Human Immunodeficiency Virus Disease: Aids and Related Disorders Anthony S. Fauci, H. Clifford Lane |
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Section 15 Infections Due to RNA Viruses
227 viral Gastroenteritis
Umesh D. Parashar, Roger I. Glass 228 Enterovirus, Parechovirus, and Reovirus Infections Jeffrey I. Cohen 229 Measles (rubeola) Kaitlin Rainwater-Lovett, William J. Moss 230e Rubella (German Measles) Laura A. Zimmerman, Susan E. Reef 231e Mumps Steven A. Rubin, Kathryn M. Carbone 232 Rabies and other Rhabdovirus Infections Alan C. Jackson 233 Arthropod-Borne and Rodent-Borne Virus Infections Jens H. Kuhn, Clarence J. Peters 234 Ebolavirus and Marburgvirus Infections Jens H. Kuhn |
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Section 16 Fungal Infections
235 Diagnosis and Treatment of Fungal Infections
John E. Edwards, Jr. 236 Histoplasmosis Chadi A. Hage, L. Joseph Wheat 237 Coccidioidomycosis Neil M. Ampel 238 Blastomycosis Donna C. Sullivan, Rathel L. Nolan, III 239 Cryptococcosis Arturo Casadevall 240 Candidiasis John E. Edwards, Jr. 241 Aspergillosis David W. Denning 242 Mucormycosis Brad Spellberg, Ashraf S. Ibrahim 243 superficial Mycoses and Less Common Systemic Mycoses Carol A. Kauffman 244 Pneumocystis Infections Henry Masur, Alison Morris |
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Section 17 Protozoal and Helminthic Infections: General Considerations
245e Laboratory Diagnosis of Parasitic Infections
Sharon L. Reed, Charles E. Davis 246e Agents Used to Treat Parasitic Infections Thomas A. Moore |
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Section 18 Protozoal Infections
247 Amebiasis and Infection with Free-Living Amebas
Rosa M. Andrade, Sharon L. Reed 248 Malaria Nicholas J. White, Joel G. Breman 249 Babesiosis Edouard G. Vannier, Peter J. Krause 250e Atlas of Blood smears of Malaria and Babesiosis Nicholas J. White, Joel G. Breman 251 Leishmaniasis Shyam Sundar 252 Chagas disease and African Trypanosomiasis Louis V. Kirchhoff, Anis Rassi Jr. 253 Toxoplasma Infections Kami Kim, Lloyd H. Kasper 254 Protozoal Intestinal Infections and Trichomoniasis Peter F. Weller |
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Section 19 Helminthic Infections
255e Introduction to Helminthic Infections
Peter F. Weller 256 Trichinellosis and Other Tissue Nematode Infections Peter F. Weller 257 Intestinal Nematode Infections Peter F. Weller, Thomas B. Nutman 258 Filarial and Related Infections Thomas B. Nutman, Peter F. Weller 259 Schistosomiasis and other Trematode Infections Charles H. King, Adel A. F. Mahmoud 260 Cestode Infections A. Clinton White, Jr., Peter F. Weller |
Part 9 Terrorism and Clinical Medicine
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Terrorism and Clinical Medicine
261e Microbial Bioterrorism
H. Clifford Lane, Anthony S. Fauci 262e Chemical Terrorism Charles G. Hurst, Jonathan Newmark, James A. Romano, Jr. 263e Radiation Terrorism Christine E. Hill-Kayser, Eli Glatstein, Zelig A. Tochner |
Part 10 Disorders of the Cardiovascular System
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Section 1 Introduction to CardiovasCular Disorders
264 Approach to the Patient with Possible Cardiovascular Disease
Joseph Loscalzo 265e Basic Biology of the Cardiovascular System Joseph Loscalzo, Peter Libby, Jonathan A. Epstein 266e Epidemiology of Cardiovascular Disease Thomas A. Gaziano, J. Michael Gaziano |
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Section 2 Diagnosis of Cardiovascular Disorders
267 Physical Examination of the Cardiovascular System
Patrick T. O’Gara, Joseph Loscalzo 268 Electrocardiography Ary L. Goldberger 269e Atlas of Electrocardiography Ary L. Goldberger 270e noninvasive Cardiac imaging: Echocardiography, Nuclear Cardiology, and Magnetic Resonance/Computed Tomography Imaging Marcelo F. Di Carli, Raymond Y. Kwong, Scott D. Solomon 271e Atlas of Noninvasive Imaging Marcelo F. Di Carli, Raymond Y. Kwong, Scott D. Solomon 272 Diagnostic Cardiac Catheterization and Coronary Angiography Jane A. Leopold, David P. Faxon |
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Section 3 Disorders of Rhythm
273e Principles of Electrophysiology
David D. Spragg, Gordon F. Tomaselli 274 The Bradyarrhythmias: Disorders of the Sinoatrial Node David D. Spragg, Gordon F. Tomaselli 275 The Bradyarrhythmias: disorders of the Atrioventricular Node David D. Spragg, Gordon F. Tomaselli 276 Supraventricular Tachyarrhythmias Gregory F. Michaud, William G. Stevenson 277 Ventricular Arrhythmias Roy M. John, William G. Stevenson 278e Atlas of Cardiac Arrhythmias Ary L. Goldberger |
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Section 4 Disorders of the Heart
279 Heart Failure: Pathophysiology and Diagnosis
Douglas L. Mann, Murali Chakinala 280 Heart failure: Management Mandeep R. Mehra 281 Cardiac Transplantation and Prolonged Assisted Circulation Sharon A. Hunt, Hari R. Mallidi 282 Congenital Heart Disease in the Adult Jamil A. Aboulhosn, John S. Child 283 Aorticvalve Disease Patrick T. O’Gara, Joseph Loscalzo 284 Mitralvalve Disease Patrick T. O’Gara, Joseph Loscalzo 285 Tricuspid and Pulmonic Valve Disease Patrick T. O’Gara, Joseph Loscalzo 286 Multiple and Mixed Valvular Heart Disease Patrick T. O’Gara, Joseph Loscalzo 287 Cardiomyopathy and Myocarditis Neal K. Lakdawala, Lynne Warner Stevenson, Joseph Loscalzo 288 Pericardial Disease Eugene Braunwald 289e Tumors and Trauma of the Heart Eric H. Awtry, Wilson S. Colucci 290e Cardiac Manifestations of Systemic Disease Eric H. Awtry, Wilson S. Colucci |
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Section 5 Coronary and Peripheral Vascular Disease
291e The Pathogenesis, Prevention, and Treatment of Atherosclerosis
Peter Libby 292e Atlas of Atherosclerosis Peter Libby 293 ischemic Heart Disease Elliott M. Antman, Joseph Loscalzo 294 Non-st-segment Elevation Acute Coronary Syndrome (non-st-segment Elevation Myocardial Infarction and Unstable Angina Christopher P. Cannon, Eugene Braunwald 295 ST-Segment Elevation Myocardial Infarction Elliott M. Antman, Joseph Loscalzo 296e Percutaneous Coronary interventions and other interventional Procedures David P. Faxon, Deepak L. Bhatt 297e Atlas of Percutaneous Revascularization Jane A. Leopold, Deepak L. Bhatt, David P. Faxon 298 Hypertensivevascular Disease Theodore A. Kotchen 299 Renovascular Disease Stephen C. Textor 300 Deep Venous Thrombosis and Pulmonary Thromboembolism Samuel Z. Goldhaber 301 Diseases of the Aorta Mark A. Creager, Joseph Loscalzo 302 Arterial Diseases of the Extremities Mark A. Creager, Joseph Loscalzo 303 Chronic Venous Disease and Lymphedema Mark A. Creager, Joseph Loscalzo 304 Pulmonary Hypertension Aaron B. Waxman, Joseph Loscalzo |
Part 11 Disorders of the Respiratory System
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Section 1 Diagnosis of Respiratory Disorders
305 Approach to the Patient with Disease of the Respiratory System
Patricia A. Kritek, Augustine M. K. Choi 306e Disturbances of Respiratory Function Edward T. Naureckas, Julian Solway 307 Diagnostic Procedures in Respiratory Disease Anne L. Fuhlbrigge, Augustine M. K. Choi 308e Atlas of Chest Imaging Patricia A. Kritek, John J. Reilly, Jr. |
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Section 2 Diseases of the Respiratory System
309 Asthma
Peter J. Barnes 310 Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia Praveen Akuthota, Michael E. Wechsler 311 Occupational and Environmental Lung Disease John R. Balmes, Frank E. Speizer 312 Bronchiectasis Rebecca M. Baron, Miriam Baron Barshak 313 Cysticfibrosis Eric J. Sorscher 314 Chronic Obstructive Pulmonary Disease John J. Reilly, Jr., Edwin K. Silverman, Steven D. Shapiro 315 Interstitial Lung Diseases Talmadge E. King, Jr. 316 Disorders of the Pleura Richard W. Light 317 Disorders of the Mediastinum Richard W. Light 318 Disorders of Ventilation John F. McConville, Babak Mokhlesi, Julian Solway 319 Sleep Apnea Andrew Wellman, Susan Redline 320e Lung Transplantation Elbert P. Trulock |
Part 12 Critical Care Medicine
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Section 1 Respiratory Critical Care
321 Approach to the Patient with Critical Illness
John P. Kress, Jesse B. Hall 322 Acute Respiratory Distress Syndrome Bruce D. Levy, Augustine M. K. Choi 323 Mechanical Ventilatory Support Bartolome R. Celli |
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Section 2 Shock and Cardiac Arrest
324 Approach to the Patient with Shock
Ronald V. Maier 325 Severe Sepsis and Septic Shock Robert S. Munford 326 Cardiogenic Shock and Pulmonary Edema Judith S. Hochman, David H. Ingbar 327 Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death Robert J. Myerburg, Agustin Castellanos |
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Section 3 Neurologic Critical Care
328 Coma
Allan H. Ropper 329e Examination of the Comatose Patient S. Andrew Josephson 330 Neurologic Critical Care, including Hypoxic-ischemic Encephalopathy, and Subarachnoid Hemorrhage J. Claude Hemphill, III, Wade S. Smith, Daryl R. Gress |
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Section 4 Oncologic Emergencies
331 Oncologic Emergencies
Rasim Gucalp, Janice P. Dutcher |
Part 13 Disorders of the Kidney and Urinary Tract
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Disorders of the Kidney and Urinary Tract
332e Cellular and Molecular Biology of the Kidney
Alfred L. George, Jr., Eric G. Neilson 333e Adaptation of the Kidney to Injury Joseph V. Bonventre 334 Acute Kidney Injury Sushrut S. Waikar, Joseph V. Bonventre 335 Chronic Kidney Disease Joanne M. Bargman, Karl Skorecki 336 Dialysis in the Treatment of Renal Failure Kathleen D. Liu, Glenn M. Chertow 337 Transplantation in the Treatment of Renal Failure Jamil Azzi, Edgar L. Milford, Mohamed H. Sayegh, Anil Chandraker 338 Glomerular Diseases Julia B. Lewis, Eric G. Neilson 339 Polycystic Kidney Disease and other Inherited Disorders of Tubule Growth and Development Jing Zhou, Martin R. Pollak 340 Tubulointerstitial Diseases of the Kidney Laurence H. Beck, David J. Salant 341 Vascular Injury to the Kidney Nelson Leung, Stephen C. Textor 342 Nephrolithiasis Gary C. Curhan 343 Urinary Tract Obstruction Julian L. Seifter |
Part 14 Disorders of the Gastrointestinal System
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Section 1 Disorders of the Alimentary Tract
344 Approach to the Patient with Gastrointestinal Disease
William L. Hasler, Chung Owyang 345 Gastrointestinal Endoscopy Louis Michel Wong Kee Song, Mark Topazian 346e Video Atlas of Gastrointestinal Endoscopy Louis Michel Wong Kee Song, Mark Topazian 347 Diseases of the Esophagus Peter J. Kahrilas, Ikuo Hirano 348 Peptic Ulcer Disease and Related Disorders John Del Valle 349 Disorders of Absorption Henry J. Binder 350e The Schilling Test Henry J. Binder 351 Inflammatory Bowel Disease Sonia Friedman, Richard S. Blumberg 352 Irritable Bowel Syndrome Chung Owyang 353 Diverticular Disease and Common Anorectal Disorders Rizwan Ahmed, Susan L. Gearhart 354 Mesentericvascularinsufficiency Rizwan Ahmed, Mahmoud Malas 355 Acute Intestinal Obstruction Danny O. Jacobs 356 Acute Appendicitis and Peritonitis Danny O. Jacobs |
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Section 2 Liver and Biliary Tract Disease
357 Approach to the Patient with Liver Disease
Marc G. Ghany, Jay H. Hoofnagle 358 Evaluation of Liver Function Daniel S. Pratt 359 The Hyperbilirubinemias Allan W. Wolkoff 360 Acute Viral Hepatitis Jules L. Dienstag 361 Toxic and Drug-induced Hepatitis William M. Lee, Jules L. Dienstag 362 Chronic Hepatitis Jules L. Dienstag 363 Alcoholic Liver Disease Mark E. Mailliard, Michael F. Sorrell 364 Nonalcoholic Fatty Liver Diseases and Nonalcoholic Tteatohepatitis Manal F. Abdelmalek, Anna Mae Diehl 365 Cirrhosis and Its Complications Bruce R. Bacon 366e Atlas of Liver Biopsies Jules L. Dienstag, Atul K. Bhan 367e Genetic, Metabolic, and Infiltrative Diseases Affecting the Liver Bruce R. Bacon 368 Liver Transplantation Raymond T. Chung, Jules L. Dienstag 369 Diseases of the Gallbladder and Bile Ducts Norton J. Greenberger, Gustav Paumgartner |
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Section 3 Disorders of the Pancreas
370 Approach to the Patient with Pancreatic Disease
Darwin L. Conwell, Norton J. Greenberger, Peter A. Banks 371 Acute and Chronic Pancreatitis Darwin L. Conwell, Peter A. Banks, Norton J. Greenberger |
Part 15 Immune-Mediated, inflammatory, and Rheumatologic Disorders
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Section 1 The Immune System in Health and Disease
372e Introduction to the Immune System
Barton F. Haynes, Kelly A. Soderberg, Anthony S. Fauci 373e the Major Histocompatibility Complex Gerald T. Nepom 374 Primary Immune Deficiency Diseases Alain Fischer 375e Primary Immunodeficiencies Associated with (or secondary to) Other Diseases Alain Fischer |
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Section 2 Disorders of Immune-Mediated Injury
376 Allergies, Anaphylaxis, and Systemic Mastocytosis
Joshua A. Boyce, K. Frank Austen 377e Autoimmunity and Autoimmune Diseases Betty Diamond, Peter E. Lipsky 378 Systemic Lupus Erythematosus Bevra Hannahs Hahn 379 Antiphospholipid Syndrome Haralampos M. Moutsopoulos, Panayiotis G. Vlachoyiannopoulos 380 Rheumatoid Arthritis Ankoor Shah, E. William St. Clair 381 Acuterheumatic Fever Jonathan R. Carapetis 382 Systemic Sclerosis (Scleroderma) and Related Disorders John Varga 383 Sjögren’s Syndrome Haralampos M. Moutsopoulos, Athanasios G. Tzioufas 384 The Spondyloarthritides Joel D. Taurog, John D. Carter 385 The Vasculitis Syndromes Carol A. Langford, Anthony S. Fauci 386e Atlas of the Vasculitic Syndromes Carol A. Langford, Anthony S. Fauci 387 Behçet’s Syndrome Haralampos M. Moutsopoulos 388 Polymyositis, Dermatomyositis, and Inclusion Body Myositis Marinos C. Dalakas 389 Relapsing Polychondritis Carol A. Langford 390 Sarcoidosis Robert P. Baughman, Elyse E. Lower 391e IgG4-Related Disease John H. Stone 392 Familial Mediterranean Fever and Other Hereditary Autoinflammatory Diseases Daniel L. Kastner |
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Section 3 Disorders of the Joints and Adjacent Tissues
393 Approach to Articular and Musculoskeletal Disorders
John J. Cush 394 Osteoarthritis David T. Felson 395 Gout and Other Crystal-Associated Arthropathies H. Ralph Schumacher, Lan X. Chen 396 Fibromyalgia Leslie J. Crofford 397 Arthritis Associated with Systemic Disease, and Other Arthritides Carol A. Langford, Brian F. Mandell 398 Periarticular Disorders of the Extremities Carol A. Langford |
Part 16 Endocrinology and Metabolism
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Section 1 Endocrinology
399 Approach to the Patient with Endocrine Disorders
J. Larry Jameson 400e Mechanisms of Hormone Action J. Larry Jameson 401e Anterior Pituitary: Physiology of Pituitary Hormones Shlomo Melmed, J. Larry Jameson 402 Hypopituitarism Shlomo Melmed, J. Larry Jameson 403 Anterior Pituitary Tumor Syndromes Shlomo Melmed, J. Larry Jameson 404 disorders of the Neurohypophysis Gary L. Robertson 405 Disorders of the Thyroid Gland J. Larry Jameson, Susan J. Mandel, Anthony P. Weetman 406 Disorders of the Adrenal Cortex Wiebke Arlt 407 Pheochromocytoma Hartmut P. H. Neumann 408 Multiple Endocrine Neoplasia Rajesh V. Thakker 409 Autoimmune Polyendocrine Syndromes Peter A. Gottlieb |
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Section 2 Reproductive Endocrinology
410 Disorders of Sex Development
John C. Achermann, J. Larry Jameson 411 Disorders of the Testes and Male Reproductive System Shalender Bhasin, J. Larry Jameson 412 Disorders of the Female Reproductive System Janet E. Hall 413 Menopause and Postmenopausal Hormone Therapy JoAnn E. Manson, Shari S. Bassuk 414 Infertility and Contraception Janet E. Hall |
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Section 3 Obesity, Diabetes Mellitus, and Metabolic Syndrome
415e Biology of Obesity
Jeffrey S. Flier, Eleftheria Maratos-Flier 416 Evaluation and Management of Obesity Robert F. Kushner 417 Diabetes Mellitus: Diagnosis, Classification, and Pathophysiology Alvin C. Powers 418 Diabetes Mellitus: Management and Therapies Alvin C. Powers 419 Diabetes Mellitus: Complications Alvin C. Powers 420 Hypoglycemia Philip E. Cryer, Stephen N. Davis 421 Disorders of Lipoprotein Metabolism Daniel J. Rader, Helen H. Hobbs 422 The Metabolic Syndrome Robert H. Eckel |
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Section 4 Disorders of Bone and Mineral Metabolism
423 Bone and Mineral Metabolism in Health and Disease
F. Richard Bringhurst, Marie B. Demay, Stephen M. Krane, Henry M. Kronenberg 424 Disorders of the Parathyroid Gland and Calcium Homeostasis John T. Potts, Jr., Harald Jüppner 425 Osteoporosis Robert Lindsay, Felicia Cosman 426e Paget's Disease and Other Dysplasias of Bone Murray J. Favus, Tamara J. Vokes |
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Section 5 Disorders of Intermediary Metabolism
427 Heritable Disorders of Connective Tissue
Darwin J. Prockop, John F. Bateman 428 Hemochromatosis Lawrie W. Powell 429 Wilson’s Disease George J. Brewer 430 The Porphyrias Robert J. Desnick, Manisha Balwani 431e Disorders of Purine and Pyrimidine Metabolism Christopher M. Burns, Robert L. Wortmann 432e Lysosomal Storage Diseases Robert J. Hopkin, Gregory A. Grabowski 433e Glycogen Storage Diseases and other Inherited Disorders of Carbohydrate Metabolism Priya S. Kishnani, Yuan-Tsong Chen 434e Inherited Disorders of Amino Acid Metabolism in Adults Nicola Longo 435e Inherited Defects of Membrane Transport Nicola Longo 436e Atlas of Clinical Manifestations of Metabolic Diseases J. Larry Jameson |
Part 17 Neurologic Disorders
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Section 1 Diagnosis of Neurologic Disorders
437 Approach to the Patient with Neurologic Disease
Daniel H. Lowenstein, Joseph B. Martin, Stephen L. Hauser 438e The Neurologic Screening Exam Daniel H. Lowenstein 439e Video Atlas of the Detailed Neurologic Examination Martin A. Samuels 440e Neuroimaging in Neurologic Disorders William P. Dillon 441e Atlas of Neuroimaging Andre D. Furtado, William P. Dillon 442e Electrodiagnostic Studies of Nervous System Disorders: EEG, Evoked Potentials, and EMG Michael J. Aminoff 443e technique of Lumbar Puncture Elizabeth Robbins, Stephen L. Hauser 444e Biology of Neurologic Diseases Stephen L. Hauser, Stanley B. Prusiner, M. Flint Beal |
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Section 2 Diseases of the Central Nervous System
445 Seizures and Epilepsy
Daniel H. Lowenstein 446 Cerebrovasculardiseases Wade S. Smith, S. Claiborne Johnston, J. Claude Hemphill, III 447 Migraine and Other Primary Headache Disorders Peter J. Goadsby, Neil H. Raskin 448 Alzheimer’s Disease and Other Dementias William W. Seeley, Bruce L. Miller 449 Parkinson’s Disease and other Movement Disorders C. Warren Olanow, Anthony H.V. Schapira, Jose A. Obeso 450 Ataxicdisorders Roger N. Rosenberg 451e Classification of the Spinocerebellar Ataxias Roger N. Rosenberg 452 Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases Robert H. Brown, Jr. 453e Prion Diseases Stanley B. Prusiner, Bruce L. Miller 454 Disorders of the Autonomic Nervous System Phillip A. Low, John W. Engstrom 455 Trigeminal Neuralgia, Bell’s Palsy, and Other Cranial Nerve Disorders M. Flint Beal, Stephen L. Hauser 456 Diseases of the Spinal Cord Stephen L. Hauser, Allan H. Ropper 457e Concussion and other Traumatic Brain Injuries Allan H. Ropper 458 Multiple Sclerosis and Other Demyelinating Diseases Stephen L. Hauser, Douglas S. Goodin |
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Section 3 Nerve and Muscle Disorders
459 Peripheral Neuropathy
Anthony A. Amato, Richard J. Barohn 460 Guillain-Barré Syndrome and Other Immune-Mediated Neuropathies Stephen L. Hauser, Anthony A. Amato 461 Myasthenia Gravis and Other Diseases of the Neuromuscular Junction Daniel B. Drachman, Anthony A. Amato 462e Muscular Dystrophies and Other Muscle Diseases Anthony A. Amato, Robert H. Brown, Jr. 463e Special Issues in Inpatient Neurologic Consultation S. Andrew Josephson, Martin A. Samuels |
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Section 4 Chronic Fatigue Syndrome
464e Chronic Fatigue Syndrome
Gijs Bleijenberg, Jos W. M. van der Meer |
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Section 5 Psychiatric and Addiction Disorders
465e Biology of Psychiatric Disorders
Robert O. Messing, Eric J. Nestler 466 Mental Disorders Victor I. Reus 467 Alcohol and Alcoholism Marc A. Schuckit 468e Opioid-related Disorders Thomas R. Kosten, Colin N. Haile 469e Cocaine and Other Commonly Abused Drugs Nancy K. Mello, Jack H. Mendelson 470 Nicotine Addiction David M. Burns 471e Neuropsychiatric Illnesses in War Veterans Charles W. Hoge |
Part 18 Poisoning, Drug Overdose, and Envenomation
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Poisoning, Drug Overdose, and Envenomation
472e Heavy Metal Poisoning
Howard Hu 473e Poisoning and drug overdose Mark B. Mycyk 474 Disorders Caused by Venomous Snakebites and Marine Animal Exposures Charles Lei, Natalie J. Badowski, Paul S. Auerbach, Robert L. Norris 475 Ectoparasite Infestations and Arthropod Injuries Richard J. Pollack, Scott A. Norton |
Part 19 Disorders Associated with Environmental Exposures
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Disorders Associated with Environmental Exposures
476e Altitude Illness
Buddha Basnyat, Geoffrey Tabin 477e Hyperbaric and Diving Medicine Michael H. Bennett, Simon J. Mitchell 478e Hypothermia and Frostbite Daniel F. Danzl 479e Heat-related Illnesses Daniel F. Danzl Appendix: Laboratory Values of Clinical Importance Alexander Kratz, Michael A. Pesce, Robert C. Basner, Andrew J. Einstein 480e The Clinical Laboratory in Modern Health Care Anthony A. Killeen 481e Clinical Procedure Tutorial: Central Venous Catheter Placement Maria A. Yialamas, William E. Corcoran, Gyorgy Frendl, Kurt Fink 482e Clinical Procedure Tutorial: Thoracentesis Charles A. Morris, Andrea S. Wolf 483e Clinical Procedure Tutorial: Abdominal Paracentesis Maria A. Yialamas, Anna E. Rutherford, Lindsay King 484e Clinical Procedure Tutorial: Endotracheal Intubation Charles A. Morris, Emily Page Nelson 485e Clinical Procedures Tutorial: Percutaneous Arterial Blood Gas Sampling Christian D. Becker Medical Editors: Sean Sadikot, Jeremy Matloff 486e Clinical Procedures Tutorial: Lumbar Puncture Beth Rapaport, Stephen Krieger, Corey McGraw Medical Editors: Sean Sadikot, Jeremy Matloff |
